Methylamine → HCID 19908223, compound

HRID 867501Notes

Reaction equation

HRID 867501 reaction equation
[H][H].[CH2:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:11][NH2:12]>>[CH2:3]([N:10]1[CH:4]2[CH2:9][CH:8]1[CH2:11][NH:12][CH2:6][CH2:5]2)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 7504BenzylamineHCID 178418361HCID 178418361, compound

Product 1

HCID 19908223HCID 19908223, compound

Procedure

Compound (I) wherein R2 is derived from compound (III) wherein n is 1, m is 2 and Q is hydrogen is formed on reacting benzylamine rather than monomethylamine with compound 16 in Scheme III. Proceeding as in Scheme III, 8-benzyl-3,8-diazabicyclo[4.1.1]octane is formed which is coupled with compound (II) and then debenzylated by catalytic hydrogenation, as before.

Workup

  1. customis formed

Sources & evidence

ORD record
ord-a530c586e52c49f59d73d48fad485246
Source dataset
uspto-grants-1988_10
Patent number
US04775668

Reaction notes

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