Ammonia → HCID 14590422, compound

Participants

Reaction Steps

7 g (20.5 mmol) of 1-[[7-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-3-yl]carbonyl]imidazole are suspended in 20 ml of N,N-dimethylformamide, whereupon the suspension is treated with 3.5 ml (about 46 mmol) of a 25 percent aqueous ammonia solution, the mixture is stirred at room temperature for 1 hour and then poured into 10 ml of water. The product is filtered off under suction after 1 hour, rinsed with water and dried at 80° in a high vacuum. There is obtained 7-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxamide of melting point 266°-268°.

Provenance & Evidence