Ammonia → HCID 14590422, compound

HRID 867524Notes

Reaction equation

HRID 867524 reaction equation
[Cl:1][C:2]1[C:7]2[C:8](=[O:24])[N:9]([CH3:23])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]([N:18]3C=CN=C3)=[O:17])[C:6]=2[CH:5]=[CH:4][CH:3]=1.N.O>CN(C)C=O>[Cl:1][C:2]1[C:7]2[C:8](=[O:24])[N:9]([CH3:23])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]([NH2:18])=[O:17])[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 962WaterHCID 13987114HCID 13987114, compound

Product 1

HCID 14590422HCID 14590422, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

7 g (20.5 mmol) of 1-[[7-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-3-yl]carbonyl]imidazole are suspended in 20 ml of N,N-dimethylformamide, whereupon the suspension is treated with 3.5 ml (about 46 mmol) of a 25 percent aqueous ammonia solution, the mixture is stirred at room temperature for 1 hour and then poured into 10 ml of water. The product is filtered off under suction after 1 hour, rinsed with water and dried at 80° in a high vacuum. There is obtained 7-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxamide of melting point 266°-268°.

Workup

  1. filtrationThe product is filtered off under suction after 1 hour
  2. washrinsed with water
  3. customdried at 80° in a high vacuum

Sources & evidence

ORD record
ord-9cd04ae1cba8401f93e5db914eacf688
Source dataset
uspto-grants-1988_10
Patent number
US04775671

Reaction notes

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