Hydrochloric Acid → HCID 22914630, compound

Participants

Reaction Steps

7.10 g (19 mmol) of ethyl 7-bromo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-3carboxylate in 30 ml of ethanol are heated to boiling for 20 minutes with a solution of 1.13 g (28 mmol) of sodium hydroxide in 15 ml of water. The solution is thereafter neutralized with 7 ml of 4N hydrochloric acid and the ethanol is removed on a rotary evaporator. After cooling the separated solid is filtered off under suction. After drying at 85° in vacuo there is obtained 7-bromo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-[1,5-a][1,4]benzodiazepine-3-carboxylic acid.

Provenance & Evidence