Hydrochloric Acid → HCID 22914630, compound

HRID 867555Notes

Reaction equation

HRID 867555 reaction equation
[Br:1][C:2]1[C:7]2[C:8](=[O:22])[N:9]([CH3:21])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]([O:18]CC)=[O:17])[C:6]=2[CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>C(O)C.O>[Br:1][C:2]1[C:7]2[C:8](=[O:22])[N:9]([CH3:21])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]([OH:18])=[O:17])[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15035559HCID 15035559, compound

Product 1

HCID 22914630HCID 22914630, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

7.10 g (19 mmol) of ethyl 7-bromo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-3carboxylate in 30 ml of ethanol are heated to boiling for 20 minutes with a solution of 1.13 g (28 mmol) of sodium hydroxide in 15 ml of water. The solution is thereafter neutralized with 7 ml of 4N hydrochloric acid and the ethanol is removed on a rotary evaporator. After cooling the separated solid is filtered off under suction. After drying at 85° in vacuo there is obtained 7-bromo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-[1,5-a][1,4]benzodiazepine-3-carboxylic acid.

Workup

  1. customthe ethanol is removed on a rotary evaporator
  2. temperatureAfter cooling the separated solid
  3. filtrationis filtered off under suction
  4. customAfter drying at 85° in vacuo

Sources & evidence

ORD record
ord-b12c23c844524cb7bf7ba73134e74991
Source dataset
uspto-grants-1988_10
Patent number
US04775671

Reaction notes

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