反应详情

6.80 g (20 mmol) of 1-[[7-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-3-yl]carbonyl]imidazole, 50 ml of N,N-dimethylformamide and 3.2 g (20 mmol) of heptanecarboxamidoxime are stirred at 100° overnight. The solution is then evaporated and the residue is dissolved in methylene chloride. The organic solution is washed with water and the solvent is evaporated. By chromatography of the residue on silica gel while eluting with ethyl acetate and subsequent recrystallization from ethyl acetate there is obtained 7-chloro-3-(3-heptyl-1,2,4-oxadiazol-5-yl)-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one of melting point 108°-110°.

1. customThe solution is then evaporated
2. dissolutionthe residue is dissolved in methylene chloride
3. washThe organic solution is washed with water
4. customthe solvent is evaporated
5. washBy chromatography of the residue on silica gel while eluting with ethyl acetate and subsequent recrystallization from ethyl acetate