Diethylamine → HCID 13318792, compound

Diethylamine (153 g) is added to a solution, maintained at 20° C., of (R)-2-chloropropionyl chloride (87.7 g) in chloroform (600 cc), in the course of 1 hour. The reaction mixture is washed with distilled water (500 cc), with an aqueous 1N hydrochloric acid solution (3×500 cc) and then with distilled water (500 cc). The organic phase is dried over sodium sulphate, filtered and then concentrated to dryness under reduced pressure (2.7 kPa) at a temperature in the vicinity of 30° C. The residue obtained is distilled under reduced pressure (17 Pa). (R)-N,N-Diethyl-2-chloropropionamide (43 g) in the form of a colourless oil [b.p.17Pa =75°-80° C.; [α]D20 =-43.3° (c=10; CHCl3)] is thereby obtained.

1. washThe reaction mixture is washed with distilled water (500 cc), with an aqueous 1N hydrochloric acid solution (3×500 cc)
2. dry with materialThe organic phase is dried over sodium sulphate
3. filtrationfiltered
4. concentrationconcentrated to dryness under reduced pressure (2.7 kPa) at a temperature in the vicinity of 30° C
5. customThe residue obtained
6. distillationis distilled under reduced pressure (17 Pa)

ORD record

ord-32107fdb4918496db84cf57afef6f557

Source dataset

uspto-grants-1988_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04775753