2-Fluoro-4-(trifluoromethyl)pyridine → 2-Azido-5-(trifluoromethyl)pyridine

HRID 867626Notes

Reaction equation

HRID 867626 reaction equation
[N:1]([C:4]1[CH:9]=[C:8](C(F)(F)F)[CH:7]=[CH:6][N:5]=1)=[N+:2]=[N-:3].FC1C=C([C:21]([F:24])([F:23])[F:22])C=CN=1>>[N:1]([C:4]1[CH:9]=[CH:8][C:7]([C:21]([F:24])([F:23])[F:22])=[CH:6][N:5]=1)=[N+:2]=[N-:3]

Participants

3

Reactant 2

HCID 111595142-Fluoro-4-(trifluoromethyl)pyridineHCID 151506942-Azido-4-(trifluoromethyl)pyridine

Product 1

HCID 151506932-Azido-5-(trifluoromethyl)pyridine

Procedure

The following were prepared analogously and analyzed by nmr spectroscopy: 2-azido-4-(trifluoromethyl)pyridine, off white crystals (from 2-fluoro-4-(trifluoromethyl)pyridine; and 2-azido-4,6-bis(trifluoromethyl)pyridine, pale yellow oil crystallizing on standing (from 2-chloro-4,6-bis(trifluoromethyl)pyridine.

Workup

  1. customThe following were prepared analogously
  2. customand 2-azido-4,6-bis(trifluoromethyl)pyridine, pale yellow oil crystallizing

Sources & evidence

ORD record
ord-6f04ff5df6b64738a0bedaf065594398
Source dataset
uspto-grants-1988_10
Patent number
US04775762

Reaction notes

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