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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 867626Generated: October 31, 2026

2-Fluoro-4-(trifluoromethyl)pyridine → 2-Azido-5-(trifluoromethyl)pyridine

https://huagongshe.com/reaction/867626

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluoro-4-(trifluoromethyl)pyridineHCID 11159514—
Reactant2-Azido-4-(trifluoromethyl)pyridineHCID 15150694—
Product2-Azido-5-(trifluoromethyl)pyridineHCID 15150693—

Reaction Steps

The following were prepared analogously and analyzed by nmr spectroscopy: 2-azido-4-(trifluoromethyl)pyridine, off white crystals (from 2-fluoro-4-(trifluoromethyl)pyridine; and 2-azido-4,6-bis(trifluoromethyl)pyridine, pale yellow oil crystallizing on standing (from 2-chloro-4,6-bis(trifluoromethyl)pyridine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04775762
Source datasetuspto-grants-1988_10
ORD IDord-6f04ff5df6b64738a0bedaf065594398
Source noteuspto-grants-1988_10