Benzoyl chloride → HCID 14032515, compound

HRID 867680Notes

Reaction equation

HRID 867680 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][N:9]=2)[CH2:4][CH2:3]1.[C:17]([Cl:25])(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[ClH:25].[C:17]([N:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([CH:5]2[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]2)=[N:9]1)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 178480237HCID 178480237, compound

Product 1

HCID 14032515HCID 14032515, compoundYield 62.2%

Procedure

A mixture of 3.0 g of 3-(1-methyl-4-piperidinyl)-1H-indazole and 3.2 ml of benzoyl chloride was heated at 100° for 2 hrs. The resultant solid was triturated with ether and collected. The salt was twice recrystallized from ethanol-ether to yield 3.1 g (62.2%) of product, mp 234°-236° C.

Workup

  1. temperaturewas heated at 100° for 2 hrs
  2. customThe resultant solid was triturated with ether
  3. customcollected
  4. customThe salt was twice recrystallized from ethanol-ether

Sources & evidence

ORD record
ord-358be1df674d4828a9838ab6f1f433e5
Source dataset
uspto-grants-1988_10
Patent number
US04775761

Reaction notes

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