Diisopropylamine → HCID 14302196, compound

Temperature

-78 °C

To a solution of anhydrous diisopropylamine (11.9 g, 0.118 mol) in 100 ml of anhydrous THF was added dropwise under argon atmosphere a solution of n-butyl lithium in hexane (1.59N, 74.2 ml, 0.118 mol) with stirring at -78° C. and further stirred for 30 min. To this solution was addded dropwise a solution of methyl isobutyrate (10.0 g, 0.098 mol) in anhydrous THF (10 ml). The resulting mixture was stirred for 30 min. HMPA (7 g, 0.039 mol) and chloromethyl propyl ether (13.8 g, 0.127 mol) were added, and stirred for 30 min. The reaction mixture was allowed to warm to room temperature. To the mixture was then added an aqueous saturated solution of ammonium chloride (300 ml) cooled in an ice bath. The organic layer was washed with 30 ml of water and with 20 ml of brine, and dried over anhydrous sodium sulfate. The solvent was distilled out successively at normal pressure and then the residue was distilled in vacuo to give a colourless and transparent oil of methyl 2,2-dimethyl-4-oxaheptylate (12.6 g, 0.0724 mol, b.p. 84°-87° C./30 mmHg, yield: 73.9%). The product was assigned the structure by the following data.

1. stirringfurther stirred for 30 min
2. stirringThe resulting mixture was stirred for 30 min
3. stirringstirred for 30 min
4. temperatureto warm to room temperature
5. temperaturecooled in an ice bath
6. washThe organic layer was washed with 30 ml of water and with 20 ml of brine
7. dry with materialdried over anhydrous sodium sulfate
8. distillationThe solvent was distilled out successively at normal pressure
9. distillationthe residue was distilled in vacuo

ORD record

ord-e743b14ce555461dbdb457b631ab152a

Source dataset

uspto-grants-1988_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04775692