Boron trifluoride etherate → HCID 13533295, compound

HRID 867842Notes

Reaction equation

HRID 867842 reaction equation
B(F)(F)F.CC[O:7]CC.[CH3:10][O:11][C:12]1[CH:17]=[C:16]([O:18][CH3:19])[N:15]=[C:14]([NH:20][C:21](SC)=[N:22][S:23]([C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)(=[O:25])=[O:24])[N:13]=1>O1CCCC1>[CH3:10][O:11][C:12]1[CH:17]=[C:16]([O:18][CH3:19])[N:15]=[C:14]([NH:20][C:21]([NH:22][S:23]([C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)(=[O:25])=[O:24])=[O:7])[N:13]=1

Participants

4

Reactant 2

HCID 8000Boron trifluoride etherateHCID 86740348HCID 86740348, compound

Product 1

HCID 13533295HCID 13533295, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 8 ml of 15% aqueous tetrahydrofuran was added with stirring 0.8 g of mercuric acid oxide and 0.56 ml of borontrifluoride etherate. The mixture was stirred for 20 minutes, and then 0.8 g of N-(4,6-dimethoxypyrimidin-2-yl)-N'-(3-pyridinylsulfonyl)carbamimidothioic acid, methyl ester was added. The slurry was stirred at room temperature for 1 hour, filtered, and the solid was rinsed with 50 ml of water, followed by 40 ml of dichloromethane, and dried to give 0.3 g of the desired product, m.p. 176° C. dec.

Workup

  1. stirringThe slurry was stirred at room temperature for 1 hour
  2. filtrationfiltered
  3. washthe solid was rinsed with 50 ml of water
  4. customdried

Sources & evidence

ORD record
ord-b13c16c1f2784425a5dc7e240d4049bf
Source dataset
uspto-grants-1988_10
Patent number
US04776878

Reaction notes

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