反应详情

A mixture of 2-methoxymethyl-4-pyrimidone (1.73 g) and phosphorus oxychloride (20 ml) were heated together under reflux for 30 minutes. The mixture was stripped, ice/water added and the pH raised to 14 (NaOH). The solution was extracted with chloroform, the extracts dried (MgSO4) and stripped to give 2-methoxymethyl-4-chloropyrimidine (1.72 g) as an oil which was used without further purification.

1. temperaturewere heated together
2. temperatureunder reflux for 30 minutes
3. extractionThe solution was extracted with chloroform
4. dry with materialthe extracts dried (MgSO4)