Sodium Hydroxide → 105950-89-8

HRID 867874Notes

Reaction equation

HRID 867874 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[NH:9][C:8](=O)[CH:7]=[CH:6][N:5]=1.[OH-].[Na+].P(Cl)(Cl)([Cl:15])=O>>[CH3:1][O:2][CH2:3][C:4]1[N:9]=[C:8]([Cl:15])[CH:7]=[CH:6][N:5]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 24813Phosphorus oxychlorideHCID 14306129HCID 14306129, compound

Product 1

HCID 14306130105950-89-8

Procedure

A mixture of 2-methoxymethyl-4-pyrimidone (1.73 g) and phosphorus oxychloride (20 ml) were heated together under reflux for 30 minutes. The mixture was stripped, ice/water added and the pH raised to 14 (NaOH). The solution was extracted with chloroform, the extracts dried (MgSO4) and stripped to give 2-methoxymethyl-4-chloropyrimidine (1.72 g) as an oil which was used without further purification.

Workup

  1. temperaturewere heated together
  2. temperatureunder reflux for 30 minutes
  3. extractionThe solution was extracted with chloroform
  4. dry with materialthe extracts dried (MgSO4)

Sources & evidence

ORD record
ord-e591d0f8a15d4229a3fc0c664a9e2d7c
Source dataset
uspto-grants-1988_10
Patent number
US04777172

Reaction notes

Loading…