Piperidine → HCID 14306131, compound

HRID 867875Notes

Reaction equation

HRID 867875 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:7][O:8][CH2:9][C:10]1[N:15]=[C:14](Cl)[CH:13]=[CH:12][N:11]=1>ClCCl>[CH3:7][O:8][CH2:9][C:10]1[N:15]=[C:14]([N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[CH:13]=[CH:12][N:11]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 14306130105950-89-8

Product 1

HCID 14306131HCID 14306131, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Piperidine (6.17 ml) in dichloromethane (40 ml) was added dropwise to a solution of 2-methoxymethyl-4-chloropyrimidine (4.71 g) in dichloromethane (40 ml). After standing overnight at room temperature the mixture was heated under reflux for 1 hour. After cooling the solution was washed with water, dried and stripped. The residue was chromatographed (silica gel, CHCl3) to give 2-methoxymethyl-4-piperidinopyrimidine (4.49 g) as an oil.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1 hour
  3. temperatureAfter cooling the solution
  4. washwas washed with water
  5. customdried
  6. customThe residue was chromatographed (silica gel, CHCl3)

Sources & evidence

ORD record
ord-90ebdf45ce7948058a334d63dc3ab216
Source dataset
uspto-grants-1988_10
Patent number
US04777172

Reaction notes

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