4-Methoxymethyl-5-methyl-6-piperidinopyrimidine → 4-Hydroxymethyl-5-methyl-6-morpholinopyrimidine

HRID 867892Notes

Reaction equation

HRID 867892 reaction equation
C[O:2][CH2:3][C:4]1[C:9]([CH3:10])=[C:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[N:7]=[CH:6][N:5]=1.COCC1C(C)=C(N2CCCCC2)N=CN=1>>[OH:2][CH2:3][C:4]1[C:9]([CH3:10])=[C:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[N:7]=[CH:6][N:5]=1

Participants

3

Reactant 2

HCID 143061614-Methoxymethyl-5-methyl-6-piperidinopyrimidineHCID 212457974-Methoxymethyl-5-methyl-6-morpholinopyrimidine

Product 1

HCID 143061664-Hydroxymethyl-5-methyl-6-morpholinopyrimidine

Procedure

Substituting 4-methoxymethyl-5-methyl-6-morpholinopyrimidine, (5.77 g), for 4-methoxymethyl-5-methyl-6-piperidinopyrimidine and using corresponding molar proportions of the other reagents in the method of Example 10(iv), gave 4-hydroxymethyl-5-methyl-6-morpholinopyrimidine, 3.46 g, m.p. 66°-68°, from petroleum ether (40/60).

Sources & evidence

ORD record
ord-98eff9ca92a44a3599bf3b432168b09b
Source dataset
uspto-grants-1988_10
Patent number
US04777172

Reaction notes

Loading…