4-Hydroxybenzaldehyde → HCID 13749609, compound

HRID 867909Notes

Reaction equation

Cl.[NH2:2][CH2:3][CH2:4][SH:5].[OH-].[Na+].[OH:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=1.[CH3:17][N:18]=[C:19]=[O:20]>>[CH3:17][NH:18][C:19]([N:2]1[CH2:3][CH2:4][S:5][CH:13]1[C:12]1[CH:15]=[CH:16][C:9]([OH:8])=[CH:10][CH:11]=1)=[O:20]

Participants

Reactant 4

HCID 1264-Hydroxybenzaldehyde

HCID 9082Cysteamine Hydrochloride

HCID 12228Methyl Isocyanate

HCID 14798Sodium Hydroxide

Product 1

HCID 13749609HCID 13749609, compoundYield 68.1%

Procedure

5.68 g of cysteamine hydrochloride, 2 g of sodium hydroxide, 6.1 g of 4-hydroxybenzaldehyde and 3.5 g of methyl isocyanate are treated in the same manner as described in paragraph 2. 8.1 g of N-methyl-2-(4-hydroxyphenyl)thiazolidine-3-carboxamide are obtained. Yield: 68.1%.

Sources & evidence

ORD record: ord-bb99744086174d33810408a0900f5b4e
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04777178

Reaction notes

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