Sodium Hydroxide → HCID 14271000, compound

HRID 867922Notes

Reaction equation

HRID 867922 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]([N:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)=O)=[CH:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>C(OCC)C>[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][N:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:2]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 12926531HCID 12926531, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 14271000HCID 14271000, compoundYield 88.5%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of 1-(3-thienylcarbonyl)pyrrolidine (12 g) in dry diethylether (200 ml) was added to a slurry of lithium aluminium hydride (2.6 g) in dry diethylether (100 ml). The mixture was stirred for 1 hour, and aqueous 5M sodium hydroxide (20 ml) was added. The mixture was filtered and the filtrate was distilled to give the title compound (9.8 g) as a colourless oil b.p. 120/15 mm.

Workup

  1. filtrationThe mixture was filtered
  2. distillationthe filtrate was distilled

Sources & evidence

ORD record
ord-1d30b787201246a5ae2d2f92d07a845f
Source dataset
uspto-grants-1988_10
Patent number
US04777179

Reaction notes

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