反应详情

3-Methyl-2-thiophenecarboxaldehyde (12 g), 1,2-ethanediol (20 ml) and a trace of toluene-p-sulphonic acid were heated at reflux in toluene (250 ml) under Dean and Stark conditions for 4 h. The reaction mixture was cooled and washed with 5% aqueous sodium carbonate solution and water. The toluene solution was evaporated to give an oil which was distilled to give the title compound as a pale yellow oil (14.5 g) b.p. 95°/0.1 mm.

1. temperatureThe reaction mixture was cooled
2. washwashed with 5% aqueous sodium carbonate solution and water
3. customThe toluene solution was evaporated
4. customto give an oil which
5. distillationwas distilled