Isopropanol → HCID 70274702, compound

HRID 867949Notes

Reaction equation

HRID 867949 reaction equation
O([C:8]([O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:9][N+:10]([O-:12])=[O:11])C1C=CC=CC=1.[NH2:20][CH2:21][CH2:22][S:23][CH2:24][C:25]1[N:26]=[C:27]([CH2:30][N:31]([CH3:33])[CH3:32])[S:28][CH:29]=1.C(O)(C)C>C(Cl)Cl>[CH3:33][N:31]([CH2:30][C:27]1[S:28][CH:29]=[C:25]([CH2:24][S:23][CH2:22][CH2:21][NH:20][C:8]([O:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[CH:9][N+:10]([O-:12])=[O:11])[N:26]=1)[CH3:32]

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 109773182-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazoleHCID 12696039HCID 12696039, compound

Product 1

HCID 70274702HCID 70274702, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 0.4 g (1.32 mmol) of 85% pure 1,1-diphenoxy-2-nitroethene, 0.35 g (1.52 mmol) of 4-[[(2-aminoethyl)thio]methyl]-N,N-dimethyl-2-thiazolemethanamine, 5 ml of isopropyl alcohol and 5 ml of methylene chloride ws stirred at room temperature for about two hours to provide N-[2-[[[2-[(dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-2-nitro-1-phenoxy-1-etheneamine in situ. The product was not isolated but used directly in the reaction described in part B.

Sources & evidence

ORD record
ord-98f18607b7b44cf99a778c9a0f83c58e
Source dataset
uspto-grants-1988_10
Patent number
US04777260

Reaction notes

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