反应详情

In 40 ml of dichloromethane was dissolved 2.0 g of 4-chloromethyl-5-methyl-1,3-dioxol-2-one, and 2.0 g of 4-chlorobenzenethiol was added. Then, 1.4 g of triethylamine was added, and the mixture was stirred at room temperature for 30 minutes. After the reaction, the solvent was evaporated under reduced pressure, and the residue was dissolved in ethyl acetate. The insoluble materials were separated by filtration, and the solvent was evaporated under reduced pressure. The residue was subjected to medium-pressure silica gel column chromatography as in Example 1. The eluate was evaporated under reduced pressure, and the residue was recrystallized from a mixed solvent of ethyl acetate and n-hexane to give 2.9 g of the captioned compound as colorless crystals.

1. additionwas added
2. customAfter the reaction
3. customthe solvent was evaporated under reduced pressure
4. dissolutionthe residue was dissolved in ethyl acetate
5. customThe insoluble materials were separated by filtration
6. customthe solvent was evaporated under reduced pressure
7. customThe eluate was evaporated under reduced pressure
8. customthe residue was recrystallized from a mixed solvent of ethyl acetate and n-hexane