Bromine → HCID 14257702, compound

HRID 867987Notes

Reaction equation

HRID 867987 reaction equation
[Cl:1][C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][C:9]2=[O:13])=[CH:4][C:3]=1[O:14][CH3:15].[Br:16]Br>C(O)(=O)C>[Br:16][CH:8]1[CH2:7][CH2:6][C:5]2[C:10](=[C:11]([Cl:12])[C:2]([Cl:1])=[C:3]([O:14][CH3:15])[CH:4]=2)[C:9]1=[O:13]

Participants

4

Reactant 2

HCID 24408BromineHCID 14257701HCID 14257701, compound

Product 1

HCID 14257702HCID 14257702, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

7,8-Dichloro-6-methoxy-1-tetralone (2.7 g, 0.011 mole) was suspended in acetic acid (45 ml) warmed slightly with stirring, and 0.57 ml of bromine in 5 ml of acetic acid was added over a 20 minute time period. The reaction mixture was stirred for 10 minutes, and then poured into 200 ml of stirred ice water. A white solid was filtered from the reaction mixture, dissolved in ether (75 ml), washed with brine, dried over MgSO4, evaporated in vacuo and directly used in the next step.

Workup

  1. temperaturewarmed slightly
  2. stirringThe reaction mixture was stirred for 10 minutes
  3. filtrationA white solid was filtered from the reaction mixture
  4. dissolutiondissolved in ether (75 ml)
  5. washwashed with brine
  6. dry with materialdried over MgSO4
  7. customevaporated in vacuo

Sources & evidence

ORD record
ord-1c19650d889a408a8dcc5c967b330507
Source dataset
uspto-grants-1988_10
Patent number
US04777281

Reaction notes

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