Hydrochloric Acid → HCID 70387864, compound

HRID 868020Notes

Reaction equation

HRID 868020 reaction equation
[ClH:1].[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH2:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[CH2:14][CH:13]([C:18]([O:20]CC)=[O:19])[CH2:12][CH2:11]2.Cl>CO>[ClH:1].[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH2:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[CH2:14][CH:13]([C:18]([OH:20])=[O:19])[CH2:12][CH2:11]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70387565HCID 70387565, compound

Product 1

HCID 70387864HCID 70387864, compoundYield 61.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4.5 g of ethyl 6-(1-imidazolylmethyl)-1,2,3,4-tetrahydro-2-naphthalenecarboxylate hydrochloride was added to a mixture of 15 ml of concentrated hydrochloric acid and 30 ml of methanol and then the mixture was heated under reflux for 20 hours. The reaction mixture was concentrated in vacuo to give 2.52 g of 6-(1-imidazolylmethyl)-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid hydrochloride as colorless prisms with m.p. 193°-223° C.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 20 hours
  3. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-6333dc6b591c46419593df211e10600c
Source dataset
uspto-grants-1988_10
Patent number
US04777257

Reaction notes

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