Methylamine → HCID 13772783, compound

HRID 868061Notes

Reaction equation

HRID 868061 reaction equation
[NH2:1][CH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8]2[C:17](F)=[C:16]3[C:11]([C:12](=[O:24])[C:13]([C:21]([OH:23])=[O:22])=[CH:14][N:15]3[CH2:19][CH3:20])=[CH:10][C:9]=2[F:25])[N:7]=1.[CH3:26][NH2:27]>>[NH2:1][CH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8]2[C:17]([NH:27][CH3:26])=[C:16]3[C:11]([C:12](=[O:24])[C:13]([C:21]([OH:23])=[O:22])=[CH:14][N:15]3[CH2:19][CH3:20])=[CH:10][C:9]=2[F:25])[N:7]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 13772776HCID 13772776, compound

Product 1

HCID 13772783HCID 13772783, compound

Conditions

Temperature
50 °C

Procedure

To 500 mg (1.37 mmol) of the 7-[2-(aminomethyl)-4-thiazolyl]-1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid was added 15 ml of 40% aqueous methylamine. The mixture was heated at 50° C. for 72 hours. The solution was taken to pH 6.5 and was filtered to give 350 mg of 7-[2-(aminomethyl)-4-thiazolyl]-1-ethyl-6-fluoro-1,4-dihydro-8-methylamino-4-oxo-3-quinolinecarboxylic acid, mp 194°-195° C.

Workup

  1. filtrationwas filtered

Sources & evidence

ORD record
ord-565d9a626a5f4523870c278b3cb9498f
Source dataset
uspto-grants-1988_10
Patent number
US04777175

Reaction notes

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