Methylamine → HCID 13772791, compound

HRID 868064Notes

Reaction equation

HRID 868064 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:17]=[C:16]3[C:11]([C:12](=[O:23])[C:13]([C:20]([OH:22])=[O:21])=[CH:14][N:15]3[CH2:18][CH3:19])=[CH:10][C:9]=2[F:24])[S:6][CH:7]=1.[CH3:25][NH2:26]>>[CH2:18]([N:15]1[C:16]2[C:11](=[CH:10][C:9]([F:24])=[C:8]([C:5]3[S:6][CH:7]=[C:3]([CH2:2][NH:26][CH3:25])[N:4]=3)[CH:17]=2)[C:12](=[O:23])[C:13]([C:20]([OH:22])=[O:21])=[CH:14]1)[CH3:19]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 21796343HCID 21796343, compound

Product 1

HCID 13772791HCID 13772791, compound

Procedure

A solution of 0.40 g 7-(4-chloromethyl-2-thiazolyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid in 100 ml 40% aqueous methylamine was stirred at room temperature overnight and evaporated to dryness. The resulting solid was crystallized from water to afford 0.33 g of the title compound, mp 216°-218° C. (dec). Analysis calculated for C17H16N3FO3S.0.2H2O: C, 55.94; H, 4.53; N, 11.51. Found: C, 55.92; H, 4.41; N, 11.18.

Workup

  1. customevaporated to dryness
  2. customThe resulting solid was crystallized from water

Sources & evidence

ORD record
ord-59b74debc65a4a369e01dba404833431
Source dataset
uspto-grants-1988_10
Patent number
US04777175

Reaction notes

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