Guanidine Hydrochloride → HCID 13772795, compound

HRID 868066Notes

Reaction equation

Cl.[NH2:2][C:3]([NH2:5])=[NH:4].CN(C)[CH:8]=[CH:9][C:10]([C:12]1[C:21]([F:22])=[C:20]2[C:15]([C:16](=[O:30])[C:17]([C:25]([O:27]CC)=[O:26])=[CH:18][N:19]2[CH2:23][CH3:24])=[CH:14][C:13]=1[F:31])=O>>[NH2:4][C:3]1[N:5]=[C:10]([C:12]2[C:21]([F:22])=[C:20]3[C:15]([C:16](=[O:30])[C:17]([C:25]([OH:27])=[O:26])=[CH:18][N:19]3[CH2:23][CH3:24])=[CH:14][C:13]=2[F:31])[CH:9]=[CH:8][N:2]=1

Participants

Reactant 2

HCID 5742Guanidine Hydrochloride

HCID 54568569HCID 54568569, compound

Product 1

HCID 13772795HCID 13772795, compound

Procedure

In a similar fashion the 7-(2-amino-4-pyrimidinyl)-1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, mp 285°-286° C. (42a) was prepared using guanidine hydrochloride and ethyl 7-(2'-dimethylaminoethenyl)carbonyl-1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate.

Sources & evidence

ORD record: ord-06ad5e0ca95b47978964675a14d4fbf2
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04777175

Reaction notes

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