Hydrogen Sulfide → HCID 13772820, compound

HRID 868096Notes

Reaction equation

HRID 868096 reaction equation
[SH2:1].[CH2:2]([O:4][C:5]([C:7]1[C:16](=[O:17])[C:15]2[C:10](=[CH:11][C:12]([C:19]#[N:20])=[C:13]([F:18])[CH:14]=2)[N:9]([CH2:21][CH3:22])[CH:8]=1)=[O:6])[CH3:3]>N1C=CC=CC=1.C(N(CC)CC)C>[CH2:2]([O:4][C:5]([C:7]1[C:16](=[O:17])[C:15]2[C:10](=[CH:11][C:12]([C:19](=[S:1])[NH2:20])=[C:13]([F:18])[CH:14]=2)[N:9]([CH2:21][CH3:22])[CH:8]=1)=[O:6])[CH3:3]

Participants

5

Reactant 2

HCID 402Hydrogen SulfideHCID 13853636HCID 13853636, compound

Product 1

HCID 13772820HCID 13772820, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 8471TriethylamineSolvent

Procedure

Hydrogen sulfide was passed through a solution of 1.50 g (5.2 mmol) 7-cyano-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylic acid ethyl ester in 25 ml pyridine and 1 ml triethylamine for five hours. After stirring overnight in a closed flask, the precipitated solid was filtered, washed with pyridine and ether, and dried to afford 1.28 g of yellowish solid of the title compound, mp 198°-199° C. (dec).

Workup

  1. filtrationthe precipitated solid was filtered
  2. washwashed with pyridine and ether
  3. customdried

Sources & evidence

ORD record
ord-64dc3d3c87134edeaa937b0dcda952bb
Source dataset
uspto-grants-1988_10
Patent number
US04777175

Reaction notes

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