6,7-Dimethoxy-2,3-quinolinedicarboxylic acid → HCID 135559189, compound

HRID 868153Notes

Reaction equation

HRID 868153 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13]C)[N:9]=[C:8]([C:15]([OH:17])=[O:16])[C:7]([C:18]([OH:20])=[O:19])=[CH:6]2>I>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[OH:13])[N:9]=[C:8]([C:15]([OH:17])=[O:16])[C:7]([C:18]([OH:20])=[O:19])=[CH:6]2

Participants

3

Reactant 1

HCID 139230016,7-Dimethoxy-2,3-quinolinedicarboxylic acid

Product 1

HCID 135559189HCID 135559189, compoundYield 60.5%

Reagents, catalysts & solvents 1

HCID 24841Hydrogen iodideSolvent

Procedure

A suspension of 8.64 g (31.17 mmol) of 6,7-dimethoxy-2,3-quinolinedicarboxylic acid in 125 ml of aqueous hydrogen iodide solution (57%) was refluxed for 3 hours. After cooling, the precipitate was filtered off by suction, washed with water and dried in vacuo to give 4.7 g (60.5%) of desired acid with melting point >300° C.

Workup

  1. temperaturewas refluxed for 3 hours
  2. temperatureAfter cooling
  3. filtrationthe precipitate was filtered off by suction
  4. washwashed with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-177af5c79e61434eb204322e134d2275
Source dataset
uspto-grants-1988_10
Patent number
US04777252

Reaction notes

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