Hydrochloric Acid → HCID 14278967, compound

Participants

Reaction Conditions

Reaction Steps

20.3 ml of 1N sodium hydroxide solution was added to a solution of 4-oxo-7,8-bis(phenylmethoxy)-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid, ethyl ester (6.61 g, 15.36 mmol) in 240 ml of water:tetrahydrofuran 1:1). After stirring overnight at 40° C., 200 ml of water was added, and the pH was adjusted to 2 with 3N hydrochloric acid. The resulting precipitate was filtered off with suction, washed with water and dried in vacuo. Yield: 5.28 g; melting point 207.8° C.

Provenance & Evidence