Hydrochloric Acid → HCID 14278967, compound

HRID 868161Notes

Reaction equation

HRID 868161 reaction equation
[OH-].[Na+].[O:3]=[C:4]1[N:9]2[CH:10]=[C:11]([O:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:12]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:13][C:8]2=[N:7][CH:6]=[C:5]1[C:30]([O:32]CC)=[O:31].O.Cl>O.O1CCCC1>[O:3]=[C:4]1[N:9]2[CH:10]=[C:11]([O:22][CH2:23][C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:12]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:13][C:8]2=[N:7][CH:6]=[C:5]1[C:30]([OH:32])=[O:31]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 14278966HCID 14278966, compound

Product 1

HCID 14278967HCID 14278967, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Conditions

Temperature
40 °C

Procedure

20.3 ml of 1N sodium hydroxide solution was added to a solution of 4-oxo-7,8-bis(phenylmethoxy)-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid, ethyl ester (6.61 g, 15.36 mmol) in 240 ml of water:tetrahydrofuran 1:1). After stirring overnight at 40° C., 200 ml of water was added, and the pH was adjusted to 2 with 3N hydrochloric acid. The resulting precipitate was filtered off with suction, washed with water and dried in vacuo. Yield: 5.28 g; melting point 207.8° C.

Workup

  1. filtrationThe resulting precipitate was filtered off with suction
  2. washwashed with water
  3. customdried in vacuo

Sources & evidence

ORD record
ord-8fdc86e3b177412c8d3d1e0d084a1367
Source dataset
uspto-grants-1988_10
Patent number
US04777252

Reaction notes

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