Phosphorus pentachloride → HCID 14278970, compound

HRID 868162Notes

Reaction equation

HRID 868162 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([O:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:10]([O:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:11][C:6]2=[N:5][CH:4]=[C:3]1[C:28]([OH:30])=O.P(Cl)(Cl)(Cl)(Cl)[Cl:32]>ClCCl>[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([O:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:10]([O:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:11][C:6]2=[N:5][CH:4]=[C:3]1[C:28]([Cl:32])=[O:30]

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 14278967HCID 14278967, compound

Product 1

HCID 14278970HCID 14278970, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a suspension of 4-oxo-7,8-bis(phenylmethoxy)-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid (1.21 g, 3.0 mmol) in 30 ml of dichloromethane was added 0.69 g (3.3 mmol) of phosphorous pentachloride at 0° C. After stirring for 90 minutes, the solid was filtered off, washed with dichloromethane and dried in vacuo. Yield: 0.91 g; melting point 152.4° C.

Workup

  1. filtrationthe solid was filtered off
  2. washwashed with dichloromethane
  3. customdried in vacuo

Sources & evidence

ORD record
ord-3061bf74d64d4c8bad1e5922c3e1e8f6
Source dataset
uspto-grants-1988_10
Patent number
US04777252

Reaction notes

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