Water → HCID 13800023, compound

HRID 868209Notes

Reaction equation

HRID 868209 reaction equation
[Al+3].[Cl-].[Cl-].[Cl-].[CH2:5]([O:7][C:8]([C:10]1[N:11]=[CH:12][C:13]2[NH:14][C:15]3[C:20]([C:21]=2[CH:22]=1)=[CH:19][CH:18]=[CH:17][CH:16]=3)=[O:9])[CH3:6].O.[C:24](Cl)(=[O:26])[CH3:25]>>[CH2:5]([O:7][C:8]([C:10]1[N:11]=[CH:12][C:13]2[NH:14][C:15]3[C:20]([C:21]=2[CH:22]=1)=[CH:19][C:18]([C:24](=[O:26])[CH3:25])=[CH:17][CH:16]=3)=[O:9])[CH3:6]

Participants

5

Reactant 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 105078Ethyl Beta-Carboline-3-CarboxylateHCID 6451240Aluminum(III) Chloride2×

Product 1

HCID 13800023HCID 13800023, compound

Procedure

400 mg of AlCl3 was suspended in 10 ml of acetyl chloride at 0° C. and 600 mg of beta-carboline-3-carboxylic acid ethyl ester was added. After 5 minutes, 600 mg of AlCl3 was added and the mixture was stirred for 1 hour. Alcohol was added and the pH adjusted to 7-8. 50 ml of water was added and the filtered mixture yielded 450 mg of raw product, which was recrystallized from ethanol/water (1:1). Mp: 290°-305° C.

Sources & evidence

ORD record
ord-c0c039efad8c487cb3c3076ff4d77d06
Source dataset
uspto-grants-1988_10
Patent number
US04778800

Reaction notes

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