Hydrochloric Acid → HCID 21288093, compound

HRID 868210Notes

Reaction equation

HRID 868210 reaction equation
CC(C)([O:4][C:5]1[S:9][C:8]([C:10](=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[CH:7][CH:6]=1)C.Cl>CO>[OH:4][C:5]1[S:9][C:8]([C:10](=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21288086HCID 21288086, compound

Product 1

HCID 21288093HCID 21288093, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

55.0 g (0.216 mol) of 1-[5-(1,1-dimethyl-ethoxy)-2-thienyl]-1-hexanone are heated under reflux in 400 ml of methanol and 24 ml of concentrated hydrochloric acid for 2.5 hours. The mixture is then evaporated in vacuo, the residue is taken up in 500 ml of ether and the mixture is washed twice with 50 ml of water each time. The organic phase is dried over sodium sulfate, filtered and evaporated. The residue (42.2 g of dark brown crystals, 99%) is digested with petroleum ether:diisopropyl ether =7:3.

Workup

  1. customThe mixture is then evaporated in vacuo
  2. washthe mixture is washed twice with 50 ml of water each time
  3. dry with materialThe organic phase is dried over sodium sulfate
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-2ece72f83b2e4aebaeca687b9c5a199c
Source dataset
uspto-grants-1988_10
Patent number
US04778803

Reaction notes

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