Hydrochloric Acid → HCID 21288106, compound

A 1000 mL four-neck flask equipped with a reflux condenser, mechanical stirrer, thermometer and a dropping funnel was charged with 149.5 g (1.0 mole) of a 98 percent, N,N,N',N'-tetramethyl-2-hydroxy-1,3-propanediamine. The flask was immersed into an ice-water bath while 197.2 g (2.0 moles) of concentrated hydrochloric acid was introduced at such a rate as to keep the temperature between 35° and 45° C. To the N,N,N',N'-tetramethyl-2-hydroxy-1,3-propanediamine dihydrochloride so obtained, 185.0 g (2.0 moles) of epichlorohydrin was added slowly, taking care that the temperature did not exceed 45° C. After the addition was completed, the temperature was raised to between 60° and 71° C. for 30 minutes. A 77.2 percent solution of the title compound was obtained.

1. customA 1000 mL four-neck flask equipped with a reflux condenser, mechanical stirrer
2. additionwas introduced at such a rate as
3. customthe temperature between 35° and 45° C

ORD record

ord-415d5e24d68943a5a60d08a22a22ed44

Source dataset

uspto-grants-1988_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04778813