Hydrochloric Acid → HCID 67825344, compound

HRID 868238Notes

Reaction equation

HRID 868238 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C@H:6]([NH:14][C@H:15]1[CH2:21][S:20][C@H:19]([C:22]2[S:23][CH:24]=[CH:25][CH:26]=2)[CH2:18][N:17]([CH2:27][C:28]([O:30]C(C)(C)C)=[O:29])[C:16]1=[O:35])[C:7]([O:9]C(C)(C)C)=[O:8].[ClH:36]>O1CCOCC1>[ClH:36].[ClH:36].[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C@H:6]([NH:14][C@H:15]1[CH2:21][S:20][C@H:19]([C:22]2[S:23][CH:24]=[CH:25][CH:26]=2)[CH2:18][N:17]([CH2:27][C:28]([OH:30])=[O:29])[C:16]1=[O:35])[C:7]([OH:9])=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14301775HCID 14301775, compound

Product 1

HCID 67825344HCID 67825344, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

302 mg of t-butyl α-{6(R)-[5-amino-1(S)-t-butoxycarbonylpentylamino]-5-oxo-2(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl}acetate (prepared as described in Example 2) were mixed with 3 ml of a 4N solution of hydrogen chloride in dioxane, and the mixture was stirred for 16 hours at room temperature. At the end of this time, the dioxane was distilled off under reduced pressure, and the residue was triturated with diethyl ether and filtered to yield 278 mg of the title compound as a powder.

Workup

  1. distillationAt the end of this time, the dioxane was distilled off under reduced pressure
  2. customthe residue was triturated with diethyl ether
  3. filtrationfiltered

Sources & evidence

ORD record
ord-538593a0e2384c88a8b3e08d417d0fe7
Source dataset
uspto-grants-1988_10
Patent number
US04778790

Reaction notes

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