Hydrochloric Acid → HCID 14234588, compound

Participants

Reaction Steps

142 mg of α-{6(R)-[7-amino-1(S)-ethoxycarbonylheptylamino]-5-oxo-2(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl}acetic acid dihydrochloride (prepared as described in Example 5) were dissolved in 1.2 ml of a 1N aqueous solution of sodium hydroxide, and the mixture was allowed to stand for 24 hours. At the end of this time, the mixture as adjusted to a pH value of 4.8 by the addition of 1N aqueous hydrochloric acid and the resulted precipitates were collected by filtration to give 112 mg of the title compound.

Provenance & Evidence