Hydrochloric Acid → HCID 14234588, compound

HRID 868239Notes

Reaction equation

HRID 868239 reaction equation
Cl.Cl.[NH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C@H:10]([NH:16][C@H:17]1[CH2:23][S:22][C@H:21]([C:24]2[S:25][CH:26]=[CH:27][CH:28]=2)[CH2:20][N:19]([CH2:29][C:30]([OH:32])=[O:31])[C:18]1=[O:33])[C:11]([O:13]CC)=[O:12].Cl>[OH-].[Na+]>[NH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C@H:10]([NH:16][C@H:17]1[CH2:23][S:22][C@H:21]([C:24]2[S:25][CH:26]=[CH:27][CH:28]=2)[CH2:20][N:19]([CH2:29][C:30]([OH:32])=[O:31])[C:18]1=[O:33])[C:11]([OH:13])=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14234584HCID 14234584, compound

Product 1

HCID 14234588HCID 14234588, compoundYield 96.8%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

142 mg of α-{6(R)-[7-amino-1(S)-ethoxycarbonylheptylamino]-5-oxo-2(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl}acetic acid dihydrochloride (prepared as described in Example 5) were dissolved in 1.2 ml of a 1N aqueous solution of sodium hydroxide, and the mixture was allowed to stand for 24 hours. At the end of this time, the mixture as adjusted to a pH value of 4.8 by the addition of 1N aqueous hydrochloric acid and the resulted precipitates were collected by filtration to give 112 mg of the title compound.

Workup

  1. customthe resulted precipitates
  2. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-d5befffbad0e45cdbfb3237fa5e3c63a
Source dataset
uspto-grants-1988_10
Patent number
US04778790

Reaction notes

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