Hydrochloric Acid → HCID 53778947, compound

HRID 868241Notes

Reaction equation

HRID 868241 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C@H:8]([NH:14][C@H:15]1[CH2:21][S:20][C@H:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:18][N:17]([CH2:28][C:29]([OH:31])=[O:30])[C:16]1=[O:32])[C:9]([O:11]CC)=[O:10].Cl>[OH-].[Na+]>[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C@H:8]([NH:14][C@H:15]1[CH2:21][S:20][C@H:19]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:18][N:17]([CH2:28][C:29]([OH:31])=[O:30])[C:16]1=[O:32])[C:9]([OH:11])=[O:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54075747HCID 54075747, compound

Product 1

HCID 53778947HCID 53778947, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

59.0 mg rel-α-{6(R)-[7-amino-1(S)-ethoxycarbonylheptylamino]-5-oxo-3(R)-phenylperhydro-1,4-thiazepin-4-yl]acetic acid (prepared as described in Example 8) were dissolved in 1.0 ml of a 0.5N aqueous solution of sodium hydroxide, and the mixture was stirred at room temperature for 3 hours. At the end of this time, the reaction mixture was adjusted to a pH value of 4.5 by the addition of 1N aqueous hydrochloric acid and was then concentrated by evaporation under reduced pressure to precipitate 45 mg of the title compound.

Workup

  1. concentrationwas then concentrated by evaporation under reduced pressure
  2. customto precipitate 45 mg of the title compound

Sources & evidence

ORD record
ord-85426f0cf1ff4db790688bddbe795b9d
Source dataset
uspto-grants-1988_10
Patent number
US04778790

Reaction notes

Loading…