Cyclohexane → t-Butyl rel-alpha-[3(S)-(8-t-butoxycarbonylamino-1-ethoxycarbonyloctylamino)-2-oxo-6(R)-phenylperhydroazepin-1-yl]acetate

Participants

Reaction Steps

1.2 g of t-butyl rel-α-[3(S)-amino-2-oxo-6(R)-phenylperhydroazepin-1-yl]acetate was treated with 2.15 g of ethyl 2-bromo-9-t-butoxycarbonylaminononanoate prepared as described in Preparation 4) in a similar manner to that described in Example 4, to afford a reaction product, which was subjected to column chromatography through silica gel using a mixture of cyclohexane and ethyl acetate in the ratio of 1:1 by volume as the eluent.

Provenance & Evidence