HRID868244

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8078

Cyclohexane

C6H12

结构：CC(C)(C)OC(=O)CN1C[C@@H](c2ccccc2)CC[C@H](N)C1=O

HCID14003452

未命名化合物

HCID21287862

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C(CCCCCCCNC(=O)OC(C)(C)C)N[C@H]1CC[C@H](c2ccccc2)CN(CC(=O)OC(C)(C)C)C1=O

HCID22840211

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

1.2 g of t-butyl rel-α-[3(S)-amino-2-oxo-6(R)-phenylperhydroazepin-1-yl]acetate was treated with 2.15 g of ethyl 2-bromo-9-t-butoxycarbonylaminononanoate prepared as described in Preparation 4) in a similar manner to that described in Example 4, to afford a reaction product, which was subjected to column chromatography through silica gel using a mixture of cyclohexane and ethyl acetate in the ratio of 1:1 by volume as the eluent.

WORKUP

后处理

customprepared
customas described in Preparation 4) in a similar manner to that
customto afford a reaction product, which

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-325d7bd5fabc4ea5a8f6387f5204d9ab
来源数据集: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04778790
来源说明: uspto-grants-1988_10

反应 SMILES

[NH2:1][C@H:2]1[CH2:8][CH2:7][C@H:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:5][N:4]([CH2:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[C:3]1=[O:23].Br[CH:25]([CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][NH:38][C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40])[C:26]([O:28][CH2:29][CH3:30])=[O:27].C1CCCCC1>C(OCC)(=O)C>[C:42]([O:41][C:39]([NH:38][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH:25]([NH:1][C@H:2]1[CH2:8][CH2:7][C@H:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:5][N:4]([CH2:15][C:16]([O:18][C:19]([CH3:20])([CH3:22])[CH3:21])=[O:17])[C:3]1=[O:23])[C:26]([O:28][CH2:29][CH3:30])=[O:27])=[O:40])([CH3:45])([CH3:44])[CH3:43]