Hydrochloric Acid → HCID 67825849, compound

Participants

Reaction Steps

2 ml of a 4N solution of hydrochloric acid in dioxane were added to 264 mg of t-butyl α-{6(R)[5-(1-t-butoxycarbonyl-4-piperidyl)-1(S)-ethoxycarbonylpentylamino]-5-oxo-2(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl}acetate (prepared as described in Example 18), and the mixture was allowed to stand at room temperature overnight. The solvent was then removed from the reaction mixture by evaporation under reduced pressure, and the residue was pulverized in diethyl ether and collected by filtration, to afford 208 mg of the title compound.

Provenance & Evidence