Hydrochloric Acid → HCID 67825849, compound

HRID 868245Notes

Reaction equation

HRID 868245 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16][CH2:17][CH2:18][C@H:19]([NH:25][C@H:26]2[CH2:32][S:31][C@H:30]([C:33]3[S:34][CH:35]=[CH:36][CH:37]=3)[CH2:29][N:28]([CH2:38][C:39]([O:41]C(C)(C)C)=[O:40])[C:27]2=[O:46])[C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:11][CH2:10]1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[ClH:1].[CH2:23]([O:22][C:20]([C@@H:19]([NH:25][C@H:26]1[CH2:32][S:31][C@H:30]([C:33]2[S:34][CH:35]=[CH:36][CH:37]=2)[CH2:29][N:28]([CH2:38][C:39]([OH:41])=[O:40])[C:27]1=[O:46])[CH2:18][CH2:17][CH2:16][CH2:15][CH:12]1[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1)=[O:21])[CH3:24]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14301760HCID 14301760, compound

Product 1

HCID 67825849HCID 67825849, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2 ml of a 4N solution of hydrochloric acid in dioxane were added to 264 mg of t-butyl α-{6(R)[5-(1-t-butoxycarbonyl-4-piperidyl)-1(S)-ethoxycarbonylpentylamino]-5-oxo-2(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl}acetate (prepared as described in Example 18), and the mixture was allowed to stand at room temperature overnight. The solvent was then removed from the reaction mixture by evaporation under reduced pressure, and the residue was pulverized in diethyl ether and collected by filtration, to afford 208 mg of the title compound.

Workup

  1. customThe solvent was then removed from the reaction mixture by evaporation under reduced pressure
  2. filtrationcollected by filtration

Sources & evidence

ORD record
ord-06418f1516404b1f8aeaf1a51c1c4cda
Source dataset
uspto-grants-1988_10
Patent number
US04778790

Reaction notes

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