Water → HCID 374897, compound

HRID 868313Notes

Reaction equation

HRID 868313 reaction equation
[C:1]([O:4][CH2:5][C:6]1[C:7](=[O:27])[N:8]2[C:12](=[CH:13][C:14]=1[CH:15]([CH2:21][CH3:22])C(OCC)=O)[C:11]1([O:26][CH2:25][CH2:24][O:23]1)[CH2:10][CH2:9]2)(=[O:3])C.O.[OH-].[Li+]>CO>[CH2:21]([CH:15]1[C:14]2[CH:13]=[C:12]3[N:8]([CH2:9][CH2:10][C:11]43[O:23][CH2:24][CH2:25][O:26]4)[C:7](=[O:27])[C:6]=2[CH2:5][O:4][C:1]1=[O:3])[CH3:22]

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 14301766HCID 14301766, compound

Product 1

HCID 374897HCID 374897, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Dissolved in 15 ml of methanol was 759 mg of ethyl 6-[(acetoxy)methyl]-α-ethyl-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizine-7-acetate (V), followed by an addition of 5 ml of water and a further addition of 420 mg of lithium hydroxide (monohydrate). The resultant mixture was stirred at room temperature for 2 hours. After removal of methanol by distillation, the residue was added first with about 10 ml of ice water and then with 1.5 ml of acetic acid, followed by stirring at room temperature for 22 hours.

Workup

  1. customAfter removal of methanol
  2. distillationby distillation
  3. additionthe residue was added first with about 10 ml of ice water

Sources & evidence

ORD record
ord-0181f169f5214f248e9d36db2539dc83
Source dataset
uspto-grants-1988_10
Patent number
US04778891

Reaction notes

Loading…