Hexane → Lithium cyclohexylisopropylamide

Temperature

-78 °C

A solution of 0.315 mL of freshly distilled isopropylcyclohexylamine in 2 mL of dry THF was placed in a 25 mL flask. A second solution was prepared by dissolving 0.315 mL of the same amine in 1.5 mL of THF in a 5 mL flask. Both solutions were cooled to -78° C. while stirring under an inert atmosphere and treated with 1.2 mL of a 1.6 M hexane solution of n-butyl lithium, dropwise from a syringe over 1.5 minutes in order to form lithium isopropylcyclohexylamide. To the first solution was added, dropwise over 6 minutes, 500 mg of (9) in 1 mL of THF. The reaction was stirred at -78° C. for 5 minutes, then a solution of 0.12 mL of diethyl carbonate in 0.5 mL of THF was added, dropwise over 10 minutes via syringe. After 3 additional minutes, the second solution of lithium isopropylcyclohexylamide was added followed by an additional 0.12 mL of diethyl carbonate. After 20 minutes at -78° C., the reaction was allowed to warm to room temperature and stir for 10 minutes following which it was neutralized with 0.2 mL of acetic acid in 2 mL of H2O. The reaction was partitioned between 100 mL of H2O and 35 mL of ether. The ether phase was separated, dried, filtered, evaporated, and the residue dried under high vacuum to give a yellow oil. It was chromatographed on 60 g of silica gel eluting with 29:1 (v/v) CH2Cl2 :EtOH. Nine mL fractions were collected. Fractions 29-51 were combined and evaporated to give 548 mg (86% yield) of the ester (10) as a clear, pale-yellow oil.

1. customA second solution was prepared

ORD record

ord-26679a7c3dbc4d169d07b1be5953acb3

Source dataset

uspto-grants-1988_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04778893