HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 868341Generated: October 30, 2026
Malonic Acid → 3-(6-Methyl-3-pyridyl)acrylic acid
https://huagongshe.com/reaction/868341
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 6-Methyl-3-pyridinecarboxaldehyde | HCID 10192566 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-(6-Methyl-3-pyridyl)acrylic acid | HCID 54140853 | 81.3% |
Reaction Steps
A mixture of 4.2 g of the crude 6-methyl-3-pyridinecarbaldehyde, 7.2 g of malonic acid, 0.5 ml of piperidine, and 25 ml of pyridine is stirred at 100° C. for 3 hours. The reaction mixture is concentrated, and 5 ml of water is added. The resulting precipitate is collected to give 4.6 g of the title compound. m.p. 221°-222° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04778796 |
|---|
| Source dataset | uspto-grants-1988_10 |
|---|
| ORD ID | ord-268d68c3999e4cdcaf8b602dc9e5bd1c |
|---|
| Source note | uspto-grants-1988_10 |
|---|
