反应详情

温度

100 °C

A mixture of 4.2 g of the crude 6-methyl-3-pyridinecarbaldehyde, 7.2 g of malonic acid, 0.5 ml of piperidine, and 25 ml of pyridine is stirred at 100° C. for 3 hours. The reaction mixture is concentrated, and 5 ml of water is added. The resulting precipitate is collected to give 4.6 g of the title compound. m.p. 221°-222° C.

1. concentrationThe reaction mixture is concentrated
2. addition5 ml of water is added
3. customThe resulting precipitate is collected