HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 868343Generated: October 31, 2026
Malonic Acid → 2-Propenoic acid, 3-(5-fluoro-3-pyridinyl)-
https://huagongshe.com/reaction/868343
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 5-Fluoropyridine-3-carbaldehyde | HCID 14141159 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-Propenoic acid, 3-(5-fluoro-3-pyridinyl)- | HCID 2784750 | 34% |
Reaction Steps
A mixture of 1.1 g of the crude 5-fluoro-3-pyridinecarbaldehyde, 1.8 g of malonic acid, 0.15 ml of piperidine, and 7 ml of pyridine is stirred at 110° C. for 2 hours. The reaction mixture is concentrated, and 20 ml of water is added. The resulting precipitate is collected and washed with cold water to give 0.5 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04778796 |
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| Source dataset | uspto-grants-1988_10 |
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| ORD ID | ord-398c328f6d974241a82489a18330cfbb |
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| Source note | uspto-grants-1988_10 |
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