反应详情

温度

110 °C

A mixture of 1.1 g of the crude 5-fluoro-3-pyridinecarbaldehyde, 1.8 g of malonic acid, 0.15 ml of piperidine, and 7 ml of pyridine is stirred at 110° C. for 2 hours. The reaction mixture is concentrated, and 20 ml of water is added. The resulting precipitate is collected and washed with cold water to give 0.5 g of the title compound.

1. concentrationThe reaction mixture is concentrated
2. addition20 ml of water is added
3. customThe resulting precipitate is collected
4. washwashed with cold water