HCID 14444197, compound → 3-Pyridinecarboxaldehyde, 6-(1-methylethyl)- (9CI)

HRID 868344Notes

Reaction equation

HRID 868344 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]([CH3:11])[CH3:10])=[N:7][CH:8]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH:9]([C:6]1[N:7]=[CH:8][C:3]([CH:2]=[O:1])=[CH:4][CH:5]=1)([CH3:11])[CH3:10]

Participants

4

Reactant 1

HCID 14444197HCID 14444197, compound

Product 1

HCID 144441983-Pyridinecarboxaldehyde, 6-(1-methylethyl)- (9CI)Yield 73.5%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

To a solution of 5.1 g of 5-hydroxymethyl-2-isopropylpyridine in 70 ml of chloroform, 20 g of active manganese dioxide is added, and the mixture is refluxed with stirring for 1 hour. The insoluble manganese dioxide is filtered off, and the filtrate is concentrated to give 3.7 g of crude 6-isopropyl-3-pyridinecarbaldehyde.

Workup

  1. temperaturethe mixture is refluxed
  2. filtrationThe insoluble manganese dioxide is filtered off
  3. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-5c0534d385a44583b88a0521eb4ff4c2
Source dataset
uspto-grants-1988_10
Patent number
US04778796

Reaction notes

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