Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-Pyridinecarboxaldehyde, 6-(1-methylethyl)- (9CI) | HCID 14444198 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 53725755 | HCID 53725755 | 84.3% |
Reaction Steps
A mixture of 3.7 g of the crude 6-isopropyl-3-pyridinecarbaldehyde, 3.9 g of malonic acid, 0.5 ml of piperidine, and 18 ml of pyridine is stirred at 110° C. for 2 hours. The reaction mixture is concentrated, and 5 ml of water is added. The resulting precipitate is collected to give 4.0 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04778796 |
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| Source dataset | uspto-grants-1988_10 |
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| ORD ID | ord-00e45fc6cc35485bab13fa901b021d95 |
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| Source note | uspto-grants-1988_10 |
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