Malonic Acid → HCID 53725755, compound

HRID 868345Notes

Reaction equation

HRID 868345 reaction equation
[CH:1]([C:4]1[N:9]=[CH:8][C:7]([CH:10]=O)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].C(O)(=O)[CH2:13][C:14]([OH:16])=[O:15].N1CCCCC1>N1C=CC=CC=1>[CH:1]([C:4]1[N:9]=[CH:8][C:7]([CH:10]=[CH:13][C:14]([OH:16])=[O:15])=[CH:6][CH:5]=1)([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 867Malonic AcidHCID 8082PiperidineHCID 144441983-Pyridinecarboxaldehyde, 6-(1-methylethyl)- (9CI)

Product 1

HCID 53725755HCID 53725755, compoundYield 84.3%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 3.7 g of the crude 6-isopropyl-3-pyridinecarbaldehyde, 3.9 g of malonic acid, 0.5 ml of piperidine, and 18 ml of pyridine is stirred at 110° C. for 2 hours. The reaction mixture is concentrated, and 5 ml of water is added. The resulting precipitate is collected to give 4.0 g of the title compound.

Workup

  1. concentrationThe reaction mixture is concentrated
  2. addition5 ml of water is added
  3. customThe resulting precipitate is collected

Sources & evidence

ORD record
ord-00e45fc6cc35485bab13fa901b021d95
Source dataset
uspto-grants-1988_10
Patent number
US04778796

Reaction notes

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